It seems that Alzheimer’s disease crops up in the news every week…..new drugs, new risk factors, compelling personal stories. Here’s a very informative article and two videos from the New York Times that humanize and sum up what the disease is about from different perspectives. Read more about it here…

A few days ago I got quite a chuckle at an article on aging and memory by David Brooks of the New York Times and thought to share it with you. David claims this will be the Century of the Bad Memory and in the era of an aging population, memory is the new sex. To read the article you need to register (free) for online access to the New York times, but you are sure to relate to the article and  have a few chuckles in the process. Worth it if you consider that laughter is also a positive contributor to brain health. Read on here….

According to the Alzheimer’s Association as many as 5 million Americans are living with Alzheimer’s disease. Alzheimer’s destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect work, lifelong hobbies or social life. Alzheimer’s gets worse over time, and it is fatal. Today it is the seventh-leading cause of death in the United States. Two recent studies, one in the US and the other in Europe, have found that those who showed signs of depression were more likely to develop Alzheimer’s. The researchers of these studies have put forth some theories as to why that may be. Read about this very interesting article from the BBC News here…

It is now well known that, for rodents, physical exercise is beneficial for brain health. Indeed, mice allowed to freely run on an exercise wheel grow more new neurons that mice not allowed to move freely. Importantly, these new neurons grow in an area crucial for memory formation: the hippocampus.

Neurogenesis (the birth and development of neurons) is difficult to estimate in the human brain as there are no way to directly count new neurons…
Recently, Small and his colleagues (2007) were able to use neuroimaging to study the effect of physical exercise on neurogenesis in humans. Their study involved a group of 11 middle-aged adults who had been exercising about four times a week, for three months. Results show exercise-related changes in the hippocampus, suggesting neurogenesis in this area.

This new study adds to the numerous results showing that physical exercise is good for the brain. Let’s keep moving then!

Read the original article here.
Read a report on the original article here.

I thought to share with you a recent interview with Founder Dr. Bernard Croisile, Neurologist, Neuropsychologist and Happy Neuron’s Chief Scientist, about age related brain decline and what can be done.

As we age, what issues do people most complain about?

When we age, certain cognitive difficulties are usually more annoying than really hindering. These difficulties are usually due to a greater sensitivity to interferences (noise, conversations with several persons), a lesser attention and greater amount of time to simultaneously analyze several pieces of informations (cooking and understanding a slightly technical conversation at the same time). Information processing is often more superficial, organizing and sorting data to be memorized occurs more slowly and producing mental images becomes more difficult. Hence, it can become more difficult to remember information and it takes more time to recall memories (names) or recent events (e.g. the reason why you actually went into a room).

Why should cognitive abilities be trained?

By training cognitive abilities, the difficulties we sometimes painfully experience in everyday life can be corrected. Studies have also shown that rich and varied cognitive stimulation can delay onsets of age related decline and Alzheimer’s Disease by a number years. Cognitive training consists of reinforcing brain plasticity which forms new connections between brain neurons, strengthens neural networks and, as scientists have recently discovered, regenerate new neural pathways.

How can cognitive functions be trained?

For a start, simple things such as having a rich social life, reading, doing crosswords or playing cards, cooking or gardening, already constitute natural and effective stimulation situations. Most important are variety, enthusiasm and motivation. However, one should be aware that cognitive functions cannot be trained like leg muscles. Even if playing bridge stimulates long-term memory for game rules and crosswords train word memory (spelling, definitions), playing cards will not help anyone find their keys or their car! It is therefore necessary to train all aspects of cognitive functions, especially those neglected by the routine of hobbies we are accustomed to. It should also added that training can only relevant when the lessons learned are applied to everyday life.

How often should one perform focused brain exercises?

We advise two to three training sessions a week, of about 45 minutes each, in order to maintain interest and alertness. Variety and frequency are most important.

When should one start worrying and see a doctor?

Memory difficulties occur at any age and under any circumstances: remembering a surname or a recipe, finding one’s glasses… These difficulties are just ordinary consequences of normal aging or of a fragile emotional state. Difficulties to concentrate are often due to anxiety, depression and stress. However, when aging, cultural knowledge and automatic movements (riding a bike, playing tennis, driving a car…) are not forgotten. Many of our actions are also often automatic, which explains the fact that one cannot always remember properly whether they have locked their door or not.

One should start worrying , as soon as these difficulties become a real handicap in daily life and occur repeatedly, such as people who cannot manage their schedule or budget any more, who always get lost and systematically forget what they have been told. In such a situation, one should seek medical advice to decide whether the person needs to see a neurologist or a geriatrician.

Thank you Dr. Croisile.

For people in their 60s, regular walking appears to lower the risk of dementia.

The finding, published this week in the medical journal Neurology, is the latest study to show that exercise helps delay some of the age related decline of body AND mind.

The recent research tracked the exercise habits of 749 men and women in Italy who were over age 65 and were in good health, with no indication of memory problems at the beginning of the study. After four years, they found that the most-frequent walkers had a 27 percent lower risk for developing vascular dementia than those people who walked the least.

What’s important about the study is that it again shows exercise doesn’t have to be excruciating to reap the benefits. “It’s important to note that an easy-to-perform moderate activity like walking provided the same cognitive benefits as other, more demanding activities,” said study author Dr. Giovanni Ravaglia of University Hospital S. Orsola Malpighi, in Bologna, Italy.

Last year, the Annals of Internal Medicine reported on a study of more than 1,700 adults over 65 that also showed regular walkers have lower dementia risk. In that study, walkers who exercised three or more times a week showed a dementia risk of 13 per 1,000 person years, but the adults who walked less often had a risk of 19.7 per 1,000 person years. That translates to a nearly 40 percent reduction in risk.

Walking may help stave off dementia because it improves cerebral blood flow and lowers the risk of vascular disease. So get out there for a good walk. Your brain, as well as your body, will thank you.

Young brains are plastic. This means that they can change and reorganize to adapt to deficits. Is it the case for older brains as well? Recent research suggests that the answer is yes!

Dilks, from John Hopkins University, and his colleagues, studied the brain of a stroke patient (B.L.). Behavioral and brain imaging evidence showed that reorganization had occurred in B.L.’s visual cortex following his stroke. This study, published in September 2007, was the first to show plasticity in this part of the adult brain.

Evidence for plasticity in the adult brain is great news for brain fitness! Healthy and fit brains may be more plastic, and thus more resistant to deficits caused by age and age-related diseases.
So… keep exercising your brain!

Read the original article here

Overindulging during the Thanksgiving holidays? Don’t feel guilty because many of the foods we eat during the festivities contain significant amounts of antioxidants. Turkey, cranberries, stuffing and even hot cocoa can deliver benefits to your brain. Read the article in Psychology Today and reach for the leftovers!

SharpBrains, Inc. provides individuals, companies and institutions with science-based information and guidance for Brain Health and Fitness. The company tracks and analyzes brain fitness research, markets, trends, and opportunities, offering clients insight and intelligence. The team at SharpBrains created a 10-point criteria checklist to help you evaluate and build a brain training program. The summary answers many common questions and explains why Happy Neuron is different from the other training sites. Read the informative 10-point checklist here…..

Canadian researcher published earlier this year a study showing that people who regularly used two languages showed signs of dementia 4 years later than people who used only one language!

It looks like bilingual brains are more resistant to the effects of cognitive decline. Previous studies by the same researchers had established that bilingual people were better at paying attention and ignoring distractions. Ellen Bialystok, the lead researcher on these studies, believes that this is because bilingual people always have to decide which language to use and suppress the other. This would provide practice in focusing attention, sorting through conflicting information and ignoring distraction.

Bilingualism may delay dementia in the same way that mental activity is thought to, that is by contributing to building cognitive brain reserve. However, we don’t know yet whether the same effects would appear if you start learning a language at 50.

Read the original journal article: Neuropsychologia, Volume 45, Feb 2007, pp.459-464